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Paul May School of Chemistry University of Bristol Molecule of the Month - October 2000

Also available: Chime Enhanced, Jmol and VRML versions.

The drug known as nandrolone (also known commercially as Deca-Durabolin) has the IUPAC name 17b-hydroxy-19-nor-4-andro-sten-3-one, and is an anabolic steroid (a muscle-building chemical) which occurs naturally in the human body, but only in tiny quantities. It is very similar in structure to the male hormone testosterone, and has many of the same effects in terms of increasing muscle mass, without some of the more unwanted side-effects such as increased body hair or aggressive behaviour. As such, it is being actively examined in clinical tests as a possible treatment for wasting diseases, and to strengthen and increase body tissue and musculature in HIV infected men. In this form it is usually injected in its decanoate form, after first being dissolved in a suitable edible oil.

However, what is detected in the drug tests is the metabolism product of this molecule, called 19-norandrosterone, which is excreted from the body in urine, making it easy to obtain samples. A limit of 2 ng per ml of urine (set by the International Olympic Committee) is the maximum concentration thought possible to occur in human body by 'natural means', and if this is exceeded the drug test is considered positive. Since some samples given by athletes have shown levels up to 100 times higher than this, the conclusion is that the athletes must have been taking extra quantities of the drug to enhance their performance.

The steroid nandrolone and its metabolite 19-norandrosterone. The structural differences between them consist of a reduction of a double bond to a single bond accompanied by a reduction of a carbonyl to a hydroxyl group in the first ring, and an oxidation of a hydroxyl sidegroup to a carbonyl in the fourth ring. These differences are shown in blue.

Below for comparison, are the more familiar steroid hormones, testosterone and progesterone. You can see that nandrolone and testosterone are almost identical, differing only by one methyl group, shown in red. Progesterone (the female pregnancy hormone) is also very similar, perhaps giving some credence to the boxer's claim mentioned below...

So, if the tests are flawed, what could be going wrong? Many excuses have been put forward to suggest why nandrolone is present in much higher concentrations than it should be. Bobsleigh racer Lenny Paul said that his positive test was due to eating a plate of spaghetti bolognese which contained beef from cattle that had been fed steroids. Although the UK Sport Nandrolone Review Group said that there was only a 'remote' possibility of meat consumption leading to a positive test, the athlete was cleared by his sporting body. Another sportsman, a boxer, said he failed his test after having sex with his pregnant wife! He too, was cleared.

Another possible explanation, often cited by athletes caught with positive tests, is that the nandrolone in their system arose from the use of protein milkshakes and the amino acid creatine, which are perfectly legal and used as dietary supplements to increase weight. But it is difficult to see how nandrolone could be produced from the benign components of these substances, unless they had been accidentally or deliberately contaminated. Subsequent testing, however, ruled out any deliberate contamination.

A much more likely theory has recently emerged from the results of a preliminary investigation at Aberdeen University. The findings are that dietary supplements themselves are harmless and produce no increased levels of nandrolone. Exercise alone, too, doesn't cause any problems. But a combination of both dietary supplements (none of which contain a banned substance) and exercise, can result in a positive nandrolone test. The reason for this is still unclear, but one theory is that there is a link between heavy training, the dehydration that goes with it, and their effects upon the components of high protein diets. Until more work is done, however, the 'nandrolone mystery' goes on...

For a much more detailed review of the issues involved in drug taking and testing in sports, see the excellent article in Chemistry in Britain (vol.36, September 2000) written by Rob Kingston.

Back to Molecule of the Month page.


Nandrolone Decanoate / Deca Durabolin / Deca 300

Brand Name: Deca-Durabolin

Also Known As: Deca, Duraxyl,Nandroxyl, Nandrolona, Deca-Durabolin, Durabol, Durabolin, NPP, Nandrodex, Decaplex, Decatrex, Decos, Durobolic, Decabol, Decabolic, Decaver, Nandrobolin, Newdec, Pylodec, Axidrol, Therabol, Zebol, Myobolin, Nandronit D, Cheribol, Growdeca, Gemdec, Nitrobol, Synobol, Grodec, Deca-Duralin

Active Ingredient: Nandrolone Decanoate

Active Life: 15-18 days

Effective Dose: Women 50-100 mg / week; Men 200-600 mg / week

Drug Class: Anabolic Androgenic Steroid

Water Retention: Yes

High Blood Pressure: Possible, dose dependent

Acne: Yes, at higher dosages or with individual sensitivity

DHT Conversion: No, but it converts to NOR-DHT with low activity

Decrease HPTA function: Yes

Aromatization: Low, but it converts to less active nor estrogens

Cycle: Bulking and cutting

What is Deca Durabolin / Nandrolone Decanoate?

Deca Durabolin is the common trade name for the active ingredient and reactant as Nandrolone Decanoate.

Nandrolone Decanoate is the most popular and widespread injectable steroid for strength and muscle growth. So Nandrolone Deca is used for bulking and even cutting cycles, as a rule in combination with other powerful anabolic steroids. Athletes buy Deca Durabolin primarily because it promotes water retention and great proteometabolism, it is more preferred for bulking than cutting goals. Certainly if you use the proper dosages of Decanoate and stack it with high efficient drugs as Dianabol and/or Sustanon, you will never be disappointed with the result and will always get nice huge toned muscles. It has to be mentioned due to Nandrolone popularity, it is one of the most counterfeited medicine. Therefore, you should better buy Nandrolone Decanoate from reliable sources.

How does Nandrolone Decanoate work? Deca Durabolin effects

On the structural level, Nandrolone is very similar to testosterone. Its molecule lacks a carbon atom at the 19th position (hence, it appears other name of Nandrolone - 19-nortestosterone). Nandrolone Decanoate possesses clearly defined and high anabolic activity (150% of testosterone) and low androgenic activity (20% of testosterone). As you see, Deca Nandrolone shows much weaker androgenic characteristics than testosterone. It has to be mentioned the fact that Nandrolone does not convert to a more powerful metabolite in androgen target tissues as it happens with Testosterone. Nandrolone Decanoate makes your muscles accumulate nitrogen, promoting nitrogen metabolism. Therefore, the more nitrogen is stored in your muscle tissue, the bigger your muscles are. Without any doubt, your diet should be high protein and high caloric to achieve the great muscle development.

Deca steroids (Nandrolone Decanoate) drawbacks

Nandrolone has an affinity for the progesterone receptors, which can obviously lead to progestin activity in the user’s body. It is one of the worst drawbacks of Deca Nandrolone. This can lead to such side effects like negative feedback suppressing of testosterone production, high rate of fat storage, erectile disfunction and rare gynecomastia. Moreover, it can take up to one month to return to normal natural testosterone production after cycle of Nandrolone. The other drawback is that Nandrolone is detected in human organism for 18 months. In case you will be undergoing drug testing you have to forget about this awesome drug.

Deca Nandrolone results / Deca Durabolin benefits

Nandrolone is almost impossible to cause undesirable estrogen side effects. Strong appearance of acne, oily skin hair loss or body hair growth may occur very rarely, ad a rule if you exceed 500-600 mg weekly dosage. Due to high active life, there is no need to inject frequently, you should do it once per week. Nandrolone Deca eliminates joint pains at the expense of increasing synovial fluid production, so you will not feel any aches in you shoulders, knee, or elbows so you are able to work hard without unpleasant and painful feelings.

Also Deca steroids can benefit your immune system, even it is used by HIV patients.

Nandrolone Decanoate Best Stacks / Deca Durabolin Cycle

Deca Durabolin is better for long-term cycles of around 8-12 weeks, as short ones of it does not bring desirable result. 300-600 mg of Deca Durabolin weekly is a proper dose for men. For females who buy Nandrolone Decanoate, it is suggested dose of 50 mg a week.

Nandrolone Decanoate may be used for bulking and cutting. A combination of Winstrol and Deca Durabolin with Halotestin or Trenbolone is one of the best cutting stacks, providing density and a greatly enhanced level of hardness to the muscle tissue.

The classic cycle Nandrolone Deca with Danabol has been basic for every bodybuilder for decades, and it as always provides magnificent muscle growth.

However, you have to know if you would like to avoid progestin activity related problems as erectile disfunction it is recommended to stack Nandrolone Deca with a Testosterone.

Post Cycle Therapy is undoubtedly necessary when your cycle includes Deca steroids. You should to begin it 3 weeks after finishing your cycle. Please take Clomid / Clomiphene Citrate or Nolvadex / Tamoxifen Citrate for 3 weeks in proper dosages. Do not forget about HCG, it may also be added to boost your testosterone level.

Nandrolone Decanoate / Deca Durabolin Dosage

200-300 mg of Deca Durabolin is the most popular dosage among beginners. Experienced athletes take 300 - 600 mg of Deca a week, this is the perfect and optimal dose for bulking. The dose less than 200 mg of Deca steroids per week does not give any visible effect. Nevertheless, do not take more than 600 mg, in this case, the risk to face with its negative side effects is too high. For females, suggested virilization-free dosage is 50 - 100 mg per week.

Nandrolone Decanoate Adverse Effects / Deca Durabolin Side Effects

Bodybuilders have to know about such progestin-based side effects of Deca Durabolin as untypical growth of breast tissue, (in other words-gynecomastia), inhibition of natural testosterone production and higher rate of fat storage. Proviron, Nolvaxyl, Bromocriptine and even Stanoxyl are used to eliminate those negative side effects.

You have to understand the Nolvadex by oneself will help a little with gynecomastia caused by Nandrolone. Nandrolone causes gynecomastia by two different ways.

First, Nandrolone Deca may act on the receptors of progesterone, as they are progestins, and possible increase of prolactin level in the blood which causes lactating. Bromo (Bromocriptine), Dostinex (Cabergoline), vitamin B-6 stop production of prolactin at the pituitary gland. Controlling estrogen levels with Aromatase inhibitors (AI) also helps here, as progestins themselves have not been proven to cause gynecomastia.

Second, Deca Nandrolone converts to Estrogen not with the random aromatising process but throw the action of organic acids or alkalines in the body that act on Nandrolone after it is converted to its 1-beta hydroxylated derivative. So as we know, too much estrogen causes gynecomastia. To prevent the second case users have to use anti-estrogens like Nolvadex / Tamoxifen. With lower levels of circulating estrogen, it seems almost impossible or very hard for progesterone gynecomastia to develop.

In addition, it is considered that Winstrol has some anti progesterone effects, and many athletes try to add it to Trenbolone and Deca cycles. Still there are not any studies confirming that Winstrol prevents gynecomastia, though it is possible since in certain tissues Stanozolol binds to the progesterone receptor as an antagonist. But it does not do this action in all tissues, and there are no clear evidences showing it binds in breast tissue.

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